Panorama is a market-leading noninvasive prenatal screening test (NIPT) that reveals your baby’s risk for genetic disorders as early as nine weeks. Panorama analyzes baby’s (placental) DNA through a simple blood draw from the mother’s arm.
ADVANTAGES OF PANORAMA
Panorama is a noninvasive prenatal test (NIPT) that analyzes fetal-placental, cell-free DNA isolated from maternal plasma as early as nine weeks into gestation. Panorama offers highly accurate, comprehensive panels to screen for fetal aneuploidies and microdeletion syndromes. Panorama has been evaluated in 12 peer-reviewed publications and in more than 60,000 pregnancies.
Non-invasive prenatal testing (NIPT) can prompt a journey that gives families time to prepare for the birth of a child with a genetic disorder. ACMG recommends that women of all ages be informed that NIPT is the most sensitive screening test for traditionally screened aneuploidies, including Down syndrome. While the prevalence of some conditions, such as Down syndrome, increases with maternal age, microdeletions occur randomly, meaning women of all ages are at equal risk. Panorama NIPT is highly accurate when compared to maternal serum screening and it poses no risk of miscarriage, unlike diagnostic procedures such as amniocentesis.
Panorama combines high accuracy with a low rate of test failure.
- Panorama incorporates maternal age and fetal fraction into the calculation of every risk score and includes fetal fraction on every report.
- Panorama only reports results on samples that meet Natera’s quality metrics. The observed redraw rate in clinical experience is 2.8%.
- Panorama’s SNP-based methodology enables high confidence calls at lower fetal fractions (2.8% or above).
- Panorama can be performed as early as nine weeks into pregnancy.
- Panorama is performed with a simple blood draw from the mother’s arm, posing no risk to the fetus.
- Panorama offers complimentary pre- and post-test information sessions with board-certified genetic counselors.
- More than 500,000 women in more than 70 countries have chosen Panorama.
- Panorama detects conditions that other tests can’t, including molar pregnancy, triploidy, and vanishing twin. It detects fetal fractions and fetal sex for both twins in dizygotic (fraternal) twin pregnancies.
- Panorama screens for Down syndrome with an accuracy rate greater than 99%.
- Panorama is the only test that differentiates between maternal and fetal DNA, which helps avoid false positives.
- Among commercially available NIPTs, Panorama has the highest published accuracy in determining the baby’s gender.
- Panorama has the highest sensitivity for 22q11.2 deletion syndrome, a common and potential severe microdeletion that impacts women equally regardless of age.
The Panorama prenatal screen is designed for women of any age and ethnicity who are at least 9 weeks pregnant. It cannot currently be used by women carrying three or more babies (triplets and above), women who have used an egg donor or surrogate carrying more than one baby (twins or triplets), or those who have received a bone marrow transplant.
Panorama screens for common genetic conditions that are caused by extra or missing chromosomes in the baby’s DNA. Panorama is the only NIPT on the market that tests for triploidy.
|Trisomy 21 (Down Syndrome)||99% (83/83)|
|Trisomy 18 (Edwards Syndrome)||96.4% (27/28)|
|Trisomy 13 (Patau Syndrome)||>99% (13/13)|
|Monosomy X (Turner Syndrome)||92.9%(13/14)|
|Sex chromosome aneuploidies||>99.99 (5/5)|
In addition, Panorama can also detect chromosomal abnormalities called Microdeletion as following.
|22q11.2 Deletion/Digeorge||90% (9/10)|
|Cri-du-chat||> 99% (24/24)|
|1p36 Deletion||>99% (1/1)|
The 22q11.2 deletion syndrome, also called Digeorge syndrome or Velo-Cardio-Facial syndrome, is caused by missing piece of chromosome number 22. About one in every 2,000 babies is born with the 22q11.2 deletion syndrome. The majority of children with this disorder have heart defects, immune system problems, and specific facial features. Most children with 22q11.2 deletion syndrome have mild-to-moderate intellectual disability and speech delays; some will also have calcium levels, kidney problems, feeding problems and/or seizures. About one in five children with the 22q11.2 deletion syndrome have autism spectrum disorder; 1 in 4 adults with 22q11.2 deletion syndrome have a psychiatric illness, like schizophrenia.
Panorama is the only non-invasive prenatal test, or NIPT, that can distinguish between each twin’s DNA, which means we can tell you:
- Whether your twins are identical (from the same egg) or fraternal or non-identical (from separate eggs)
- The gender of each twin
Knowing whether twins are identical can impact the care plan your healthcare provider will create for you
- Identical twins may share a placenta, which can increase the chance for unequal growth and a condition called twin-twin transfusion syndrome (TTTS). Fraternal twins are not at risk for TTTS. Knowing whether twins are identical helps healthcare providers determine the appropriate amount of follow-up and what specialists may be necessary for your pregnancy.
Panorama helps identify risk for more conditions than any other NIPT for twins
Panorama can provide risk evaluation for:
Down syndrome, Edwards syndrome, and Patau syndrome
- Turner syndrome, a genetic disorder that occurs in girls that is associated with heart defects, learning difficulties, and infertility*
- 2 deletion syndrome, a genetic disorder that occurs in boys and girls that is associated with learning differences, heart defects, and other birth defects*
*Risk evaluation available for pregnancies determined by Panorama to involve identical twins.
Most results will be returned to your doctor within 7-10calendar days. The sample will be sent andtest at the lab to be certified standards in the USA.
- A low risk result indicates that it is very unlikely that your baby is affected by one of the conditions on the Panorama panel.
- A high risk result does not mean the baby has a chromosomal abnormality; rather, it indicates a very high probability that your baby may have that condition. Your healthcare provider may recommend that you speak with a genetic counselor and/ or maternal fetal medicine specialist. You may be offered invasive diagnostic testing such as amniocentesis or CVS. No irreversible pregnancy decisions should ever be made based on a Panorama result alone.
- In a small percentage of cases, Panorama may not be able to obtain sufficient information from your blood sample to determine an accurate result. If this occurs, a second blood sample may be requested.
Frequently asked Questions
1. Panorama is tested at a lab certified by Natera in Thailand or in USA. It is not sent to China.
2. Panorama uses a different technique from others, which means Panorama can differentiate the DNA from mother and baby that is mixed in the mother’s blood, before analyzing the DNA of the baby.
3. Panorama can screen up to 10 chromosome abnormalities (chromosome 13, 18, 21, X, Y and 5 microdeletion syndromes)
4. Panorama can perform the test as early as 9 weeks gestation age.
5. Panorama can determine the gender of the baby with 99.9% accuracy.
6. Panorama has the lowest false positive if compare with other NIPT test.
7. Panorama are published in medical journals around the world. And it has published new technologies continuously.
8. Panorama has a team of obstetrician and medical genetics professionals to provide consultation with the mother.
9. Panorama has the highest total amount of cases in the USA.
10. Panorama will verify the results from the amniotic fluid without charge if the Panorama test results are reported as high-risk.
- Women carrying three or more babies (triplets and above)
- Women who have used an egg donor or surrogate carrying more than one baby (twins or triplets)
- Women who have received a bone marrow transplant.
The costs for Panorama NIPT are different each hospital and clinic. Therefore, the patients may contact the hospitals and clinic directly for accurate information. You may contact us in the chat box below or leave a message to get a referral to the clinic nearest to you.