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Renasight™ is a genetic test performed using a blood sample to determine whether impaired kidney function has a genetic cause, or whether an individual has an increased risk of developing kidney disease in the future based on family history. The test results provide clinically actionable information that helps physicians plan appropriate care and treatment. In some cases, early detection may also help slow the progression of kidney diseas
What does Renasight™ test for ?
Renasight™ analyzes 397 genes that have been carefully curated by genetics experts to provide meaningful information for medical decision-making. The test can identify genetic disorders with
  • Autosomal Dominant
  • Autosomal Recessive
  • X-linked disorders
Associated with:
  • Chronic Kidney Disease: CKD
  • Nephrolithiasis
  • Electrolyte disorders
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Patient Profiles for Testing (Patient Profile)

  • Patients with unknown or unclear etiology or atypical presentation.
  • Family history of kidney disease
  • Pre-transplant workup- donor
  • Pre-transplant workup- recipient
  • Known Clinical Diagnosis (such as Alport Syndrome,Focal Segmental Glomerulosclerosis (FSGS), Cystic disease etc.)

Renasight™ Key highlight

Comprehensive Panel, Custom-Designed for Nephrology
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Carefully curated analysis of 397 genes using Next-Generation Sequencing (NGS) technology.
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Identifies recessive, and X-linked autosomal recessive, and X-linked disorders, as well as the APOL1 risk allele
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Panel-wide single-nucleotide variant (SNV) and copy-number variant (CNV) detection
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Reports out pathogenic and likely pathogenic variants hand-selected by genetic experts to provide actionable information
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Results available in ~3 weeks
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International Standards: Samples are sent for examination at an American laboratory with ISO 15189/15190 standards and CAP

Renasight™ Can Enhance Patient Care

Recent NEJM paper identified the importance of genetics in individualized treatments
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Renasight™ Can Enhance Patient Care

  • 89% of patients with a genetic etiology of CKD had implications for clinical management.
  • 1 in 10 patients with Chronic Kidney Disease (CKD) have a genetic diagnosis.
  • A published study that analyzed the first 1,000 Renasight™ tests6 revealed a high diagnostic yield, spanning common and rare genetic conditions. The study reported that 1 in 4 patients had a positive genetic finding.
  • Approximately 1 in 2 patients were carriers, and could share this information with family members.

Downloads

Renasight Conditions List
[Download]